Storrs — DeAndre Daniels had a career-high 26 points and grabbed eight rebounds as UConn routed DePaul 99-78 on Tuesday.
Ryan Boatright scored 22 points and Shabazz Napier added 16 points, eight rebounds and seven assists for UConn (11-3, 1-1 Big East), which led from start to finish.
The Huskies opened up a 20-point halftime lead, and DePaul (10-6, 1-2) could get no closer than 12 in the second half.
Brandon Young led all scorers with career-high 35 points for the Blue Demons and Cleveland Melvin chipped in 18.
DePaul, which was coming off a win at Providence, played without starters Donnavan Kirk and Charles McKinney, who were suspended for an unspecified violation of team rules.
The 99 points was the most against a Big East opponent since the Huskies scored 117 in a six-overtime loss to Syracuse in the 2009 Big East tournament.